While I saw some aqueducts (complex structures that carry water) along the way, I doubt that these ancient travelers had access to many of the "luxuries" offered in Rome: running water, toilets and baths.
The land that Appia Antica covered was also not always part of the Roman Republic and, later, the Roman Empire. The Roman republic was often at war with rival groups. These other tribes, like the Latins, Sabines, and Etruscans, were not always friendly to those people who were traveling to and from Rome.
I wrote a bit about how people adapted to this environment by building traveler-friendly rest spots.
However, people not only adapted to the environment to make it more-traveler friendly, they also adapted the environment itself to benefit many Romans. As I mentioned, you can see many aqueducts along the Appian Antica. These structures that carried water long distances helped to sustain life for the people of Rome, quite like the ancient road itself.